Partial escape of HIV-1 from cytotoxic T lymphocytes during chronic infection.
نویسندگان
چکیده
Viral mutational escape from CD8(+) cytotoxic T lymphocytes (CTLs) is typically considered to be a dichotomous process and uncommon during chronic HIV-1 infection. Ex vivo passaging of HIV-1 from persons with chronic infection, however, revealed the evolution of many fixed substitutions within and around CTL-targeted regions, with an associated increase in replicative capacity. This indicates an evolution of mutations during chronic HIV-1 infection that trade replicative fitness for incomplete evasion of CTLs, or "partial escape."
منابع مشابه
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عنوان ژورنال:
- Journal of virology
دوره 86 13 شماره
صفحات -
تاریخ انتشار 2012